Team of Indian experts find a way to limit the progression of Huntington's disease
This is a moment of pride for India. A team of researchers at the Department of Genetics at Delhi University have found a way to restrict the progression of Huntington’s disease by increasing the insulin signaling in the brain cells. Insulin is a key component of memory processing.
The study has found that increasing the level of insulin signaling enriched the proteins that are needed for cellular functioning and survival. This in turn restores the cellular transcription system and stops the disease from progressing.
The cellular transcription system regulates gene activity and collapses in people with Huntington's disease.
The insulin signaling pathway, which is a critical controller of cellular metabolism and energy, is severely affected in Huntington’s, which has no cure at the moment.
People who are affected lose the ability to walk, talk, think, and reason. This disease begins between the age 30 and 45 years. Every person with the gene for the disease will eventually develop the disease.
Huntington's is an autosomal dominant genetic disorder. This means that if one parent carries the gene, the children have a 50/50 chance of inheriting the disease. The study found that improving the level of insulin signaling rejuvenates the neuronal cells which are otherwise stressed during disease condition.
Experts believe the the study has great potential application. Follow up investigations that include drugs to fight diabetes may offer a new way to battle such disorders.