One more reason to stay fit - obesity may cause early onset of Alzheimer's
The link between ageing and Alzheimer’s disease is well known. Now a new study says that obesity during middle age may lead to the early development of this brain disorder as well.
The study says that ageing, combined with a high fat and high sugar diet, leads to higher inflammation and stress in the hippocampus, which is responsible for long-term memory as well the prefrontal cortex, which is responsible for complex cognitive, emotional and behavioural function.
Both brain regions are involved in the progression of Alzheimer’s disease.
The study looked at a mouse model to examine the effects of an fat causing diet on insulin signalling, which is the process that tells the body how to use sugar.
One group of mice received a high-fat, high-sugar diet while the control group had a normal diet.
The study has added to the basic understanding of the pathways involved in the early progression of Alzheimer’s disease. It also shows the negative effects of a high fat and high sugar diet on the brain, say experts.